Abstract
Abstract A novel flow injection chemiluminescence (CL) analysis method for the determination of metoclopramide in the presence of sodium dodecyl sulfonate (SDS) surfactant micelles is described. This method is based on the luminescent properties of the KMnO 4 –HCHO–metoclopramide in acid medium sensitized by SDS. The optimized experimental conditions were evaluated and the possible mechanism was discussed. The CL increase is linearly related to the concentration of metoclopramide in the range 0–80.0 μg/ml with a detection limit of 31.3 ng/mL (S/N=3).The relative standard deviation for 20.0 μg/ml samples was 2.6% ( n =11). The proposed method has been successfully applied to the determination of metoclopramide in tablets.
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