Abstract
A sensitive flow injection (FI) procedure was developed for the determination of the UV-filter octyl dimethyl PABA in sunscreen formulations based on its chemiluminescence (CL) induced by potassium permanganate in sulfuric acid. Both second-order and log–log calibration graphs can be used to perform the analysis. Ninety injections per hour can be carried out, which means a sample throughput of 18 h −1 if five injections per solution are performed. The limit of detection (3 σ) was 25 ng ml −1. The interference effects of the excipient and other UV filters are studied. Sunscreen formulations containing octyl dimethyl PABA were analysed by both the proposed FI-CL method and a liquid chromatography reference method. The two methods gave comparable results.
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