Abstract
Flow injection analysis (FIA) with amperometric detection using a carbon paste electrode is applied to the determination of naltrexone. The sample solution was injected into the carrier stream of 0.1 M perchloric acid, being determined by oxidation at + 1.0V vs. Ag/ AgCl/ sat. KCl using a flow rate of 4 ml min −1. A relative standard deviation of 1.5% was calculated for a concentration level of 10 −5 M ( n = 17) without carrying out a carbon paste electrode pretreatment. Calibration curves were found to be linear between 2 × 10 −8 and 10 −5 M (almost three orders of magnitude) and the method has a detection limit of 2 × 10 −8 M. A simple and reproducible procedure is proposed for the determination of naltrexone in pharmaceuticals. The results compared favourably with those obtained by an HPLC-UV method.
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