Abstract
Biography Vellalore Kakkanaiah, PhD serves as the director of the flow cytometry group, which is part of the Biomarker Laboratories at PPD Richmond, VA. His team is focused on the development of flow cytometry methods to support drug development. Recently, his team developed a simple whole blood assay to study the cellular kinetics of CAR-T cells after adoptive cell therapy in multiple myeloma patients. Prior to joining PPD, Dr Kakkanaiah was a senior scientist at SurroMed, Inc. where he developed micro volume laser scanning cytometry assays. He earned a doctorate in immunology from Madurai Kamaraj University in India and then served as a postdoctoral fellow at Virginia Tech. His postdoctoral training involved the first identification of mature CD4-CD8 T cells by flow cytometry from the thymus of an autoimmune mouse model. He was also a fellow of the Arthritis Foundation at the UNC-Chapel Hill. Vellalore N Kakkanaiah speaks to the International Journal of Pharmacokinetics about his experience in developing flow cytometry assays for measuring cellular kinetics in adoptive cell therapies. Flow cytometry is new to bioanalysis and is being used for measuring the cellular kinetics of infused cells from adoptive cell therapy. Here, he discusses the challenges in developing flow cytometry methods for monitoring the infused CAR-T cells.
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