Abstract
Circulating tumor cells are cells that detach from the primary tumor site and migrate to the bone marrow or other tissues where they can initiate a metastatic site. Liquid biopsies are an emerging tool in the past decades that enables us to detect Circulating Tumor Cells in patients’ blood. Flow cytometry is a powerful tool used in liquid biopsy diagnostics. This aims to prove the sensitivity and specificity of a flow cytometric panel for the detection of CTCs in breast cancer patients using healthy individuals’ samples as controls. The study was blinded to the data analyzing researcher. Statistical analysis followed and results show 86.9% area under the curve which indicates that the particular method can be very promising for diagnosing breast cancer.
Highlights
Circulating tumor cells are cells that detach from the primary tumor site and migrate to the bone marrow or other tissues where they can initiate a metastatic site
Flow cytometry is a powerful tool used in liquid biopsy diagnostics
Circulating tumor cells are a rare population of cells that shed from the primary tumor and are known to be found even at a very low number in the blood circulation of cancer patients
Summary
Circulating tumor cells are a rare population of cells that shed from the primary tumor and are known to be found even at a very low number in the blood circulation of cancer patients. This subset of cancer cells is often associated with the rise of metastatic sites and cancer-related morbidity [1]. Many studies have shown that their number can be correlated with disease progression and poor prognosis in various carcinomas [2] [3] [4] [5] [6] Up to this date, the only FDA approved system for CTC detection and enu-.
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