Flow Cytometric Analysis of Peripheral T lymphocyte Subpopulations in Psoriasis

Abstract

Background : Psoriasis is a common inflammatory skin disorder, has received attention as a target for new pathogenesis and oriented therapies . Autoimmunity and T lymphocyte subsets are suggested to be involved in the development of psoriasis. The aim of this work is to asses the role of T lymphocyte subsets in the pathogenesis of psoriasis . Material And Methods :We investigated the peripheral blood lymphocyte subpopulations obtained from psoriatic patient before and after treatment and from healthy controls, using two colour flow cytometry. Results :We found highly significant suppression of total CD3+ T Cells and CD3+ CD56+ NKT lymphocytes in psoriatic patient as compared to control. Also, we observed significant reduction of T helper cells in patients as compared to control. Conclusion : The highly significant reduction of CD3+ T cell and CD3+ CD56+ NKT lymphocytes proved their actively involvement in the development of psoriasis.