Abstract
Abstract Early Growth Response 1 (EGR1) is a zinc finger transcription factor that is transiently up-regulated in T and B lymphocytes in response to mitogenic stimuli. It activates transcription of target genes required for cell division and differentiation. In T cells, EGR1 is known to integrate TCR signaling pathways with signaling cascades resulting from co-stimulation and cytokine ligation. In this study, we developed and characterized a novel monoclonal antibody for human EGR1 that can be used for intracellular (nuclear) staining and flow cytometric analysis. Using this antibody we have analyzed stimulatory requirements for the expression of this transcriptional regulator in human peripheral blood T cells.
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