Abstract
FLOCK (flare clock) system is a novel platform that comprises of a nanoporous membrane based multilayer stack that works with passively secreted sweat. It is designed to capture eczema severity and circadian disruption caused due to its symptoms. This is aimed to be a wearable designed for efficient management of the flaring associated with Atopic Dermatitis (AD). The work presents the development of an eczematous flare tracker that detects Interleukin-31 and cortisol levels to create an AD management platform. The platform uses electrochemical detection for tracking these biomarkers in sweat. It is sensitive to IL-31 levels in various flare-based formulations tested through simulated sweating with a detection limit of 50 pg/mL and range 50–1000 pg/mL. On-body study highlights the ability of the wearable platform to track the rise and fall in the biomarkers’ levels. These levels are well correlated to salivary levels and commercial gold standard techniques (r > 0.8, R2 > 0.95).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.