Floating microspheres: Emerging delivery system for diabetes mellitus

Abstract

In order to increase bioavailability, stability, and target the drug to a specific region at a predetermined rate, floating microspheres, multi-unit drug delivery systems, are designed to accomplish controlled or delayed drug administration. In clinical practise, drugs that have an upper small intestine absorption window may benefit the most from a controlled drug delivery system with an extended stomach residence period. The non-uniformity of medication absorption throughout the gastrointestinal tract and the heterogeneity of gastrointestinal (GI) transit time across and among subjects are the two key issues. The most common drug delivery systems in these applications are floating or hydrodynamically controlled. Gastro retentive medication delivery is a method of extending the length of gastric residency because it targets site-specific drug release for local or systemic effects in the upper gastrointestinal tract (GIT). Due to the uniform distribution of these multiple-unit dose forms in the stomach, which encourages more repeatable medicine absorption and a lower risk of local discomfort, floating microspheres are becoming more and more popular. Compared to single-unit dosing variants, these systems offer more benefits. The physiology of stomach emptying is briefly examined in the context of floating drug delivery systems in this paper. This review's objective is to compile the most recent research on preparation techniques and other factors that affect the functionality and characterization of floating microspheres.