FLOATING DRUG DELIVERY SYSTEM OF NSAIDS TO INCREASE GASTRIC RETENTION TIME IN UPPER PART OF GASTROINTESTINAL TRACT

Abstract

The purpose of the present work is to prolong the gastric residence time of Lornoxicam by developing gastric floating drug delivery system. Lornoxicam is non-steroidal anti-inflammatory drugs. Its short half life 2 to 3 hrs and maximal absorption of upper part of gastrointestinal tract. The residence time of the dosage form in the stomach depends upon various factors like pH, size of the dosage form, food intake, and biological factors which include age, body weight gender, posture, and diseased states Floating tablet prepared by melt granulation techniques, using bees wax as a binder and the other polymers include HPMC 50cPs,15cPs,5cPs and Sodium Alginate. The Prepared granules were then evaluated for Precompression Properties. The best batches were then tabulated, and Evaluation was carried out for the following parameters with in vitro release, buoyancy, Floating Lag timed. Batch F12 and F13 Showed best Floating time of 12hrs and Floating Lag time of 60 second.