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Abstract
An electrochemical flexible biosensor composed of gold (Au), molybdenum disulfide nanoparticles (MoS2 NPs), and Au (Au/MoS2/Au nanolayer) on the polyethylene terephthalate (PET) substrate is developed to detect envelope glycoprotein GP120 (gp120), the surface protein of HIV-1. To fabricate the nanolayer on the PET substrate, Au is sputter coated on the flexible PET substrate and MoS2 NPs are spin coated on Au, which is sputter coated once again with Au. The gp120 antibody is then immobilized on this flexible electrode through cysteamine (Cys) modified on the surface of the Au/MoS2/Au nanolayer. Fabrication of the biosensor is verified by atomic force microscopy, scanning electron microscopy, and cyclic voltammetry. A flexibility test is done using a micro-fatigue tester. Detection of the gp120 is measured by square wave voltammetry. The results indicate that the prepared biosensor detects 0.1 pg/mL of gp120, which is comparable with previously reported gp120 biosensors prepared even without flexibility. Therefore, the proposed biosensor supports the development of a nanomaterial-based flexible sensing platform for highly sensitive biosensors with flexibility for wearable device application.
Highlights
Flexible biosensors composed of polymer materials have recently attracted significant attention for their application in wearable devices and point-of-care (POC) diagnostic systems
The flexible biosensor based on a Au/MoS2/Au nanolayer on a polyethylene terephthalate (PET) substrate was developed to detect gp120 with high sensitivity
To develop the flexible biosensor, the Au/MoS2/Au nanolayer was fabricated by Au sputter coating and MoS2 NPs spin coating onto a flexible PET substrate
Summary
Flexible biosensors composed of polymer materials have recently attracted significant attention for their application in wearable devices and point-of-care (POC) diagnostic systems. In order to fabricate flexible biosensors, various types of nanomaterials such gold nanoparticles (GNPs), carbon nanotubes (CNTs), and graphene oxide (GO) have been introduced for granting the conductivity, enhancing the electron transfer, and biocompatibility [3,4,5,6,7,8]. Among these nanomaterials, carbon-based nanomaterials have been widely used due to their exceptional properties such as excellent electrical conductivity, high specific activated surface area, and chemical/biological stability [9,10]. To fabricate an excellent flexible biosensor, PET can be an excellent candidate as the flexible substrate due to its properties including low cost, excellent thermal conductivity, chemical resistance, and dimensionally stability compared with previously used PI substrate [17,18]
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