Abstract
Epilepsy is a common neurological disorder. There is still a lack of methods to accurately detect cortical activity and locate lesions. In this work, a flexible electrocorticography (ECoG) electrode array based on polydimethylsiloxane (PDMS)-parylene was fabricated to detect epileptiform activity under glutamate (Glu) and gamma-aminobutyric acid (GABA) modulation on primary somatosensory cortex of rats. The electrode with a thickness of 20 μm has good flexibility to establish reliable contact with the cortex. Fourteen recording sites with a diameter of 60 μm are modified by electroplating platinum black nanoparticles, which effectively improve the performance with lower impedance, obtaining a sensitive sensing interface. The electrode enables real-time capturing changes in neural activity under drug modulation. Under Glu modulation, neuronal populations showed abnormal excitability, manifested as hypsarrhythmia rhythm and continuous or periodic spike wave epileptiform activity, with power increasing significantly. Under GABA modulation, the excitement was inhibited, with amplitude and power reduced to normal. The flexible ECoG electrode array could monitor cortical activity, providing us with an effective tool for further studying epilepsy and locating lesions.
Highlights
Epilepsy is a common neurological disorder, affecting about 50 million people worldwide [1,2]
We demonstrated that neuronal populations of primary somatosensory cortex showed hypsarrhythmia rhythm and continuous or periodic spike wave electrical signals at epileptiform state, with an increase in both amplitude and power
We designed and fabricated a flexible ECoG electrode array based on PDMS and parylene for real-time recording of cortical neural activity
Summary
Epilepsy is a common neurological disorder, affecting about 50 million people worldwide [1,2]. Electroencephalography (EEG) is recognized as the main basis for diagnosis of epilepsy [7] It monitors abnormal changes in brain electrical activity through scalp electrodes, which play an important role in detecting and predicting seizures [8]. Polydimethylsiloxane (PDMS) [16,17], parylene [18,19], and polyimide (PI) [20,21] have been widely used as substrate materials to fabricate flexible electrodes, reducing tissue damage, and improving recording reliability [22]. We fabricated a flexible ECoG electrode array based on PDMS and parylene with a high spatial resolution for recording the neural activity on the primary somatosensory cortex of rats and facilitate the detection and localization of cortical lesions
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