Abstract
A new quinone derivative, flexibilisquinone (1), was isolated from the cultured soft coral Sinularia flexibilis, originally distributed in the waters of Taiwan. The structure of quinone 1 was established by extensive spectroscopic methods, particularly 1D and 2D NMR experiments. In the in vitro anti-inflammatory effects test, quinone 1 was found to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 proteins of the LPS-stimulated RAW264.7 macrophage cells.
Highlights
Soft corals belonging to the genus Sinularia are well-recognized as marine organisms containing various natural products that show interesting bioactivities [1,2]
The IR absorptions bands at 3490, 1736, 1680 and 1642 cm–1 were characteristic of hydroxy, ester and quinone moieties, and the latter deduction was further supported by the UV absorptions at λmax 262 and 267 nm
The result clearly depicts an up-regulation of iNOS and COX-2 proteins in LPS-stimulated murine macrophage cell line
Summary
Soft corals belonging to the genus Sinularia are well-recognized as marine organisms containing various natural products that show interesting bioactivities [1,2]. In previous studies on the chemical constituents of cultured octocorals, a series of interesting secondary metabolites were obtained from Erythropodium caribaeorum [3], Klyxum simplex [4,5,6,7], Lobophytum crassum [8], Sarcophyton trocheliophorum [9], Sinularia flexibilis [10], Sinularia leptoclados [11], Briareum excavatum [12,13,14,15,16,17,18,19,20] and Briareum sp. CGH2XX, a bacterium originally isolated from a cultured soft coral Lobophytum crassum [22,23]. During the course of our further investigation on new natural substances from the cultured soft coral Sinularia flexibilis (Figure 1), a new quinone derivative, flexibilisquinone (1), has been isolated
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