Abstract
Evaluate the effect of flaxseed, olive and fish oil on the lipid profile, preservation of villosities and lymphocyte migration in the intestinal mucosa of Wistar rats. Thirty Wistar male rats were divided into four groups, which received the AIN-93M diet, with changes only to their lipid source: flaxseed, olive, fish, and soy oil (control group). The serum was separated for the biochemical parameter analysis. A histological evaluation was performed in the ileal portion. The group which was fed fish oil presented lower values when compared to the other treatments for Total Cholesterol, High-density Lipoprotein Cholesterol and Triacylglycerol (p<0.05). The animals treated with fish and olive oils presented better intestinal villosities preservation. Less deposition of lymphocytes was observed in the flaxseed group (p<0.001). This study demonstrated that flaxseed, olive and fish oils present different responses than soy oil for the intestinal mucosa preservation and lymphocyte proliferation in Wistar rats.
Highlights
The role diet components in the prevention or in the genesis of diseases, as well as their activity mechanisms, have been the object of studies for decades
Trying to understand the activity of different oils, this study proposed to compare the effect of soybean oil to the effect of other oils on the lipid profile, preservation of villosities and lymphocyte migration in the intestinal mucosa of Wistar rats
The composition of the oils as well as the concentration of fatty acids is listed in Table 1, where the Z-6/Z-3 relation of the diet offered can be observed
Summary
The role diet components in the prevention or in the genesis of diseases, as well as their activity mechanisms, have been the object of studies for decades. Olive, flaxseed and fish oils, among others, present several beneficial effects to the organism because they are important sources of oleic acid (omega-9), Įlinolenic acid (ALA - omega-3) and eicosapentaenoic acid/ docosahexaenoic acid (EPA/DHA) respectively[2]. The modulation of these fatty acids in the diets plays an important role in the prevention and treatment of coronary heart diseases[3], hypertension[4], auto-immune disorders and cancer, presenting good results for inflammatory responses[5]. Recent investigations have shown the morphophysiological importance of the intestinal loops associated with the nutrient absorption processes[10]
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