Abstract
Simple SummaryDiabetes mellitus is a metabolic condition that affects millions of people globally. The present study highlights the enhanced activity of flaxseed lignans and polyphenols isolated from Linum usitatissimum in streptozotocin (STZ)-induced diabetic rats. Treatment with flaxseed extract showed enhanced glycosylated hemoglobin and blood glucose levels and reduced plasma cholesterol, low-density lipoprotein (LDL) cholesterol and triglycerides, urea and uric acid intensities, and plasma creatinine in the treated diabetic experimental animals, indicating beneficial effects—results sustained by histopathological observations of liver, pancreas, kidney, and spleen. Translation of this nutraceutical-based approach still requires further elucidation of its mechanism of action toward clinical applications.Flaxseeds play an important role in human health due to their chemical composition and recognized beneficial outcomes. This study investigated the antidiabetic effects of present lignans and polyphenols found in the flaxseed extract on streptozotocin (STZ)-induced diabetic rats. The flaxseed administration produced favorable changes in body weight, food and water intake, and glycosylated hemoglobin and blood glucose quantities in the treated diabetic rats. Additionally, significant positive results were observed in the biochemical parameters, namely reduced plasma cholesterol, LDL cholesterol and triglycerides, plasma creatinine, and urea and uric acid levels, highlighting the seeds’ use in traditional medicine. The results were sustained by histopathological observations that showed better tissue preservation following the flaxseed diet. Overall, the consumption of flaxseeds produced moderate reduction in glucose levels and hyperlipidemia, together with improvement in the impaired organs’ function in diabetic rats. The daily administration of polyphenols and lignans compounds could impact therapeutic potential in diabetes management.
Highlights
IntroductionFlaxseed (Linum usitatissimum), one of the oldest cultivated crops, remains valued for fiber, oil, and food production, and for potential health benefits [1]
The results revealed that secoisolariciresinol diglucoside (SDG) significantly reduces hyperglycemia while controlling the blood glucose and serum lipid intensities, regulating the metabolic equilibrium, and maintaining tissue function, leading to improved sensitivity and response of target cells to insulin
SDG, LARI, MATA, PINO, and SECO lignans and GAE, p-coumaric, and t-ferrulic acids polyphenols were identified in the material
Summary
Flaxseed (Linum usitatissimum), one of the oldest cultivated crops, remains valued for fiber, oil, and food production, and for potential health benefits [1]. The nutritional composition of flaxseed comprises about 39% oil, 18% protein, and 30% total dietary fiber [2]. The oil is predominantly in the form of triacylglycerides and includes. Flaxseed protein contains higher amounts of arginine, glutamic, and aspartic acids [4]. It is an abundant source of phenolic products, such as isolariciresinol (ISO), hidroximataresinol (HYDMA), lariciresinol (LARI), matairesinol (MATA), pinoresinol (PINO), secoisolariciresinol (SECO), and secoisolariciresinol diglucoside (SDG)
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