Abstract
A chemical investigation of callus cultures of Dysosma versipellis led to the isolation of five new flavonol dimers, dysoverines A−E (1−5), together with 12 known compounds (6−17). The structures of new compounds were determined by the extensive spectroscopic data analyses. The biosynthetic pathway of the new compounds was proposed to involve O-methylation, prenylation, and Diels–Alder cycloaddition, which successively occurred in cultured plant cells. Compounds 1−17 exhibited in vitro neuraminidase inhibitory activities with the IC50 values of 31.0−93.9μM.
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