Abstract
The aging of mammals is accompanied by the progressive atrophy of tissues and organs and the accumulation of random damage to macromolecular DNA, protein, and lipids. Flavonoids have excellent antioxidant, anti-inflammatory, and neuroprotective effects. Recent studies have shown that flavonoids can delay aging and prolong a healthy lifespan by eliminating senescent cells, inhibiting senescence-related secretion phenotypes (SASPs), and maintaining metabolic homeostasis. However, only a few systematic studies have described flavonoids in clinical treatment for anti-aging, which needs to be explored further. This review first highlights the association between aging and macromolecular damage. Then, we discuss advances in the role of flavonoid molecules in prolonging the health span and lifespan of organisms. This study may provide crucial information for drug design and developmental and clinical applications based on flavonoids.
Highlights
Aging is thought to be one of the risk factors for chronic diseases responsible for the most morbidity, mortality, and health care consumption worldwide [1,2]
Accordingto totheir theirdifferent different etary aging diseases. According to their different dietary moleculesto toprevent preventaging, aging and ways ways of of interfering interfering with with aging, aging, anti-aging anti-aging flavonoids flavonoids are are divided divided into into senolytic senolytic flavoflavoways of interfering with anti-aging flavonoids are divided into senolytic flavowaysofofinterfering interfering with aging, anti-aging flavonoids are divided into senolytic flavoways with aging, anti-aging flavonoids are divided into senolytic flavonoids, noids, noids, senomorphic senomorphic flavonoids, flavonoids, and and antisenescence antisenescence activity activity (Table (Table 1)
Senolytic quercetin plus dasatinib and fisetin have been used in the clinical treatment of osteoporosis, diabetic kidney disease, Alzheimer’s disease, and other aging-related diseases
Summary
Aging is thought to be one of the risk factors for chronic diseases responsible for the most morbidity, mortality, and health care consumption worldwide [1,2]. In phase I clinical trials in patients with diabetic kidney disease [7] and idiopathic lung disease [8], dasatinib administration with quercetin has been shown to effectively reduce the expression of the aging markers p16 and SA-β-gal. More flavonoids, such as fisetin and luteolin, have been found to eliminate senescent cells and have anti-aging effects [9,10]. We summarize the latest research on flavonoids anti-aging benadministration with quercetin hasto been shown effectively the expression of the efits More such fisetin and luteolin, have paired the cellSA-β-gal. We summarize the latest research progress on flavonoids with anti-aging benefits
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