Flavonoids isolated from Sinopodophylli Fructus and their bioactivities against human breast cancer cells

Abstract

Four prenylated flavonoids compounds 1–4, named sinopodophyllines A–D, and a flavonoid glycoside (compound 13), sinopodophylliside A, together with 19 known compounds (compounds 5–12 and 14–24) were isolated from the fruits of Sinopodophyllum hexandrum. The structures of new compounds were elucidated by extensive spectroscopic analysis, including HRESIMS, 1D and 2D NMR. Compounds 1–6, 9–11, and 14–17 were tested for their cytotoxicity against human breast-cancer T47D, MCF-7 and MDA-MB-231 cells in vitro, and compounds 2, 5, 6, 10 and 11 showed significant cytotoxicity (IC50 values < 10 μmol·L−1) against T47D cells.