Abstract
Methanolic extract of the leaves of Bridelia stipularis was studied. From this study, we isolated three known flavonoids. They were identified as 7-O-methyl luteolin, apigenin and 5, 7, 2’, 5’ tetrahydroxyflavone by NMR spectroscopic studies. All of them are first time documented for this plant. Different solvent fractions were subjected to in vitro antioxidant and cytotoxicity studies. Both apigenin and ethyl acetate soluble fraction of Bridelia stipularis showed strong antioxidant activity having IC50 value of 8.005, 8.77 μg/mL respectively. Chloroform soluble fraction of Bridelia stipularis exerted the highest toxicity to brine shrimp and petroleum ether soluble fraction showed moderate toxicity having LC50 value of 1.05, 1.71 μg/mL respectively.
Highlights
In the developing world, about 25% of ingredients in the prescribed modern medicine are derived from the extracts of medicinal plant [1]
We isolated three known flavonoids. They were identified as 7-O-methyl luteolin, apigenin and 5, 7, 2’, 5’ tetrahydroxyflavone by NMR spectroscopic studies
Three known flavonoids have been isolated from the methanolic fraction of the leaves of Bridelia stipularis
Summary
In the developing world, about 25% of ingredients in the prescribed modern medicine are derived from the extracts of medicinal plant [1]. Bridelia is a plant genus of the family Phyllanthaceae first described as a genus in 1806 [3]. It includes 60 - 70 species [4]. A wide range of biological activities have been reported by Bridelia stipularis e.g. antibacterial and antifungal activity [7], anti-candidal [8], antioxidant [9], anti-diabetic [10], cytotoxicity [7] and thrombolytic [11]. We mention isolation of three flavonoids from the leaves of Bridelia stipularis along with its in vitro antioxidant and cytotoxicity activity. All of them are very first time reported for this plant
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