Abstract
The buds of horse chestnut (Aesculus hippocastanum L., Hippocastanaceae family) is a new promising species of medicinal plant raw material. The prospect of studying the buds of this plant is due to the content of flavonoids in them, which have a wide range of pharmacological effects. Flavonoids are interesting for their capillary-strengthening action, which allows them to be used in the treatment of chronic venous insufficiency. This fact is consistent with the practice of using drugs from other organs of horse chestnut (seeds, leaves) as venotonic and angioprotective drugs. In addition, flavonoids are also characterized by antioxidant, anti-inflammatory, antimicrobial and antifungal activity.
 The actuality of the study of horse chestnut buds as a new type of medicinal plant material is also supported by the need to develop of the new effective and safe drugs based on the raw materials of this plant.
 The aim of this study was to determine the flavonoid composition of the buds of Aesulus hippocastanum. In the course of the work from the buds of horse chestnut by the method of column chromatography on silica gel L 100/160 was for the first time there were isolated and characterized using 1H-NMR, 13C-NMR, UV spectroscopy and mass spectrometry the flavonoid compounds rhamnocitrin (7-O-methylkaempferol), and accompanying 7,4′-dimethylkaempferol. The dominant and diagnostic significant flavonoid for the horse chestnut buds is rhamnocitrin. The results indicate the prospects for further study of the buds of the horse chestnut as a new type of medicinal plant raw materials.
Highlights
Актуальность изучения почек каштана конского как нового вида лекарственного растительного сырья подкреплена также необходимостью разработки новых эффективных и безопасных лекарственных препаратов на основе сырья данного растения
The results indicate the prospects for further study of the buds of the horse chestnut as a new type of medicinal plant raw materials
The buds of horse chestnut (Aesculus hippocastanum L., Hippocastanaceae family) is a new promising species of medicinal plant raw material
Summary
Объектом исследования являлись почки каштана конского обыкновенного, собранные в марте 2018 г. в Ботаническом саду Самарского университета (Самара). Содержащие соединение 1, объединяли и подвергали очистке методом перекристаллизации смесью хлороформа с этанолом. Содержащие соединение 2, также объединяли и подвергали очистке методом перекристаллизации смесью хлороформа с этанолом. 1Н-ЯМР спектр (300 МГц, ДМСО-d6, δ, м.д., J/Гц): 3.88 (3Н, с, СН3О), 6.35 (1Н, д, 2 Гц, Н-6), 6.73 (1Н, д, 2 Гц, Н-8), 6.93 (2Н, д, 9 Гц, Н-3′ и Н-5′), 8.08 (2Н, д, 9 Гц, Н-2′ и Н-6′), 12.37 (1H, c, 5-ОН группы). 1Н-ЯМР спектр (300 МГц, ДМСО-d6, δ, м.д., J/Гц): 3.85 (3Н, с, СН3О при С-4′), 3.88 (3Н, с, СН3О при С-7), 6.36 (1Н, д, 2 Гц, Н-6), 6.73 (1Н, д, 2 Гц, Н-8), 7.13 (2Н, д, 9 Гц, Н-3′ и Н-5′), 8.18 (2Н, д, 9 Гц, Н-2′ и Н6′), 12.38 (1H, c, 5-ОН группы). Масс-спектр (EI-MS, 180 °С, m/z): М+ 314 (65%), 271 (8%), 167 (4%), 135 (15%)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
