Flavonoids and other constituents of Hymenostegia afzelii (Caesalpiniaceae)

Abstract

Phytochemical investigation of the stem bark and leaves of Hymenostegia afzelii resulted in the isolation of three new flavonoids, named afzelin A-C ( 1–3), together with five known compounds: 7,6-(2″,2″-dimethylpyrano)-3,5,4′-trihydroxyflavone, apigenin, 3- O-α- l-rhamnopyranosylcincholic acid, 3- O-β- d-glucopyranosylcincholic acid, and dodecanoic acid 1,1′-[(1 S)-1-(hydroxymethyl)-1,2-ethanediyl] ester. The structures of 1–3 were determined by means of spectroscopic methods. Compounds 1–3 were tested in vitro for their preliminary cytotoxicity using the Artemia salina assay.