Abstract
Nutraceutical products possess various anti-inflammatory, antiarrhythmic, cardiotonic, and antioxidant pharmacological activities that could be useful in preventing oxidative damage, mainly induced by reactive oxygen species. Previously published data showed that a mixture of polyphenols and polyunsaturated fatty acids, mediate an antioxidative response in mdx mice, Duchenne muscular dystrophy animal model. Dystrophic muscles are characterized by low regenerative capacity, fibrosis, fiber necrosis, inflammatory process, altered autophagic flux and inadequate anti-oxidant response. FLAVOmega β is a mixture of flavonoids and docosahexaenoic acid. In this study, we evaluated the role of these supplements in the amelioration of the pathological phenotype in dystrophic mice through in vitro and in vivo assays. FLAVOmega β reduced inflammation and fibrosis, dampened reactive oxygen species production, and induced an oxidative metabolic switch of myofibers, with consequent increase of mitochondrial activity, vascularization, and fatigue resistance. Therefore, we propose FLAVOmega β as food supplement suitable for preventing muscle weakness, delaying inflammatory milieu, and sustaining physical health in patients affected from DMD.
Highlights
We observed a significant decrease of reactive oxygen species (ROS) production in C2C12 cells treated with FLAVOmega β compared to CTRL dimethyl sulfoxide (DMSO) (p = 0.0040) at 72 h after treatment, and in C2C12 treated with
It should be noted that the overall decrease in ROS production observed at 48 h compared to 24 h, for all experimental groups, could be attributed to the adaptation of the cell population to the culture conditions following splitting [21]
In Western blot analysis, we found a sustained expression of PAX7 and MyoD1 protein in 3-month-old mdx mice treated with FLAVOmega β
Summary
Dietary supplementation is an important source of vitamins, minerals, herbs, or products made from plants, animals, algae, seafood, or yeasts, intended to complement the common diet in physiological or pathological conditions. Food supplements may be useful for the maintenance of a proper nutrient supply to promote health span and improve physical performance of healthy subjects, in case of nutritional deficiencies and as an adjuvant tool for the management of multiple disease conditions. Neuromuscular disorders, such as Duchenne muscular dystrophy (DMD), present important secondary pathologic features that fulfil the requirements for dietary supplementation. DMD is an X-linked recessive disease that affects muscular function and strength
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