Abstract
Simple SummaryChemotherapy-induced peripheral neuropathy (CIPN) is a debilitating condition that severely reduces the quality of life of a considerable proportion of cancer patients. There is no cure for CIPN to date. Here, we explore the potential of flavonoids as pharmacological agents in combating CIPN. Flavonoids alleviate CIPN by reducing oxidative stress, inflammation, and neuronal damage, among other mechanisms. Future research should evaluate the efficacy and side effects of flavonoids in human models of CIPN.Purpose: This study aimed to assess the potential of flavonoids in combating CIPN. Methods: PubMed and Google Scholar were used, and studies that investigated flavonoids in models of CIPN and models of neuropathic pain similar to CIPN were included. Only studies investigating peripheral mechanisms of CIPN were used. Results: Flavonoids inhibit several essential mechanisms of CIPN, such as proinflammatory cytokine release, astrocyte and microglial activation, oxidative stress, neuronal damage and apoptosis, mitochondrial damage, ectopic discharge, and ion channel activation. They decreased the severity of certain CIPN symptoms, such as thermal hyperalgesia and mechanical, tactile, and cold allodynia. Conclusions: Flavonoids hold immense promise in treating CIPN; thus, future research should investigate their effects in humans. Specifically, precise pharmacological mechanisms and side effects need to be elucidated in human models before clinical benefits can be achieved.
Highlights
Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, Doha 24144, Qatar; Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, These authors contributed to the manuscript
The neurotoxic effects of anticancer drugs lead to neuropathy in about 70% of cancer patients [1]
One hundred thirty-four results were obtained for the combination “flavonoids” AND “Chemotherapy-induced peripheral neuropathy (CIPN)”, 6620 for “flavonoids” AND
Summary
Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, Doha 24144, Qatar; Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, These authors contributed to the manuscript. Simple Summary: Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating condition that severely reduces the quality of life of a considerable proportion of cancer patients. There is no cure for CIPN to date. We explore the potential of flavonoids as pharmacological agents in combating CIPN. Flavonoids alleviate CIPN by reducing oxidative stress, inflammation, and neuronal damage, among other mechanisms. Future research should evaluate the efficacy and side effects of flavonoids in human models of CIPN
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have