Abstract
The signaling pathways regulated by mitochondria involve among others, the intrinsic apoptotic pathway, calcium homeostasis and reactive oxygen species signaling, and ATP synthesis. The aim of this review is to narrate the importance of flavanoids (e.g., flavones, flavones, flavonols, flavonols-3-ols, anthocyanidins and isoflavones) in mitochondrial biogenesis. Therefore, the induction of mitochondrial biogenesis can be stimulated by nutrition by stimulating pathways that are responsible for activating certain kinases such as AMPK, p38 MAPK and Sirtuin 1, thereby signaling the expression of PGC-1α the conductor of mitochondrial biogenesis.
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