Abstract
In the present study, urinary excretion of the flavonoid metabolites of Persea americana was investigated. Aqueous extract of the leaves of P. americana was administered by gastric probe to Sprague–Dawley rats and urine samples were collected daily for five days. The urine samples were analyzed by reversed-phase HPLC–UV detection. The result obtained showed extensive degradation of the flavonoid of P. americana within the first day. The phenylalkyl acids detected, 3,4-dihydroxyphenylacetic acid (I), hippuric acid (II), 3-hydroxyphenylacetic acid (III), 3-methoxy-4-hydroxyphenylacetic acid (IV), 3-(4-hydroxyphenyl)propionic acid (V) and benzoic acid (VI) were confirmed by their HPLC retention times or by cochromatography with reference standards. No flavonoid glycosides or aglycones were detected in the urine samples.
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