Abstract
Rutin has a cardiotonic action on the isolated frog heart and contracts blood-vessels of toad's hind limbs and of rabbit's ears, but it has no significant effect on the blood pressure of rabbit. Rutin has also a suppressive action on the movement of the isolated rabbit's intestine as well as a slight diuretic action. Administered intravenously rutin is excreted in the urine at the rate of 22.61-44.16 % in 2.5 hours. Rutin has some influences on the blood-picture of rabbits : there is initial increase in erythrocytes and leucocytes count which is later decreased. No apparent changes are observed on the clotting time of the blood. Moreover, rutin has specific effects on adrenaline, e. g. the inhibition of its oxidation, the potentiation of its action and the sensitization to adrenaline. On the other hand rutin has an inhibitory effect on the Schwartzman phenomenon, testicular hyaluronidase activity, lung bleeding under low pressure and on the diffusion.with the Menkin factor. Furthermore it was proved that rutin was a stronger capillary stabilizer than hesperidin. Quercetin manifests similar but more stronger effect than rutin.
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