Flare-up of Nonalcoholic Steatohepatitis After Hepatectomy Resulted in Hepatic Failure in a Patient with Type 2 Diabetes Mellitus

Abstract

Nonalcoholic steatohepatits (NASH) is seen in roughly 30% of obese patients and may progress to cirrhosis in 5–30% [1, 2]. Although the clinical spectrum of NASH has not been fully clarified, so far typical NASH is usually considered to be static or only slowly progressive [1, 2]. Accumulating data suggest that NASH is a possible cause of cryptogenic cirrhosis [2, 3]. On the other hand, several case reports have indicated that some of the patients with suspected silent NASH represent progressive liver failure due to an acute exacerbation [4–6]. However, to our knowledge there has been no histopathological evidence demonstrating that cryptogenic cirrhosis turns into frank NASH. We report herein an autopsy case of flare-up NASH after hepatectomy for hepatocellular carcinoma in an obese