Flaccid bullae in a male undergoing chemotherapy

Abstract

verification, but may be normal in the face of complete deficiency with recent ascorbic acid intake. Reverse phase high-performance liquid chromatography used in the quantification of ascorbic acid in lymphocytes is the most accurate test, but this test is not routinely available. At times, the most practical diagnostic marker is clinical improvement after ascorbic acid treatment, which involves a daily oral dose of 500 to 1000 mg in adults and 100 to 300 mg daily in infants and children. Prevention can be maintained with a daily oral dose of 60 to 100 mg of ascorbic acid, where women, diabetics, smokers, and elderly require the higher end of daily dosing because of increased antioxidant demands. The presentation of nontraumatic purpura, corkscrew hairs accentuated with perifollicular petechiae, and poor dentition are significant clues to the diagnosis of this potentially fatal but treatable disease. For this series, the recommended choices are as follows: 1, d; 2, e; 3, a; 4, c; 5, e.