Abstract
Objective: The Malononitrilamides FK778 (MNA715) and FK779 (MNA279) are new derivates of A771726, the active metabolite of leflunomide. FK778 directly interacts with T- and B-cell function by inhibition of de-novo pyrimidine synthesis. It is effective in prevention of cardiac allograft rejection in several animal models. The adhesion molecules ICAM-1 and VCAM-1 are important mediators of T-cell adhesion and T-cell costimulation. We investigated the effect of FK778 on adhesion molecule upregulation early after cardiac transplantation.
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