Abstract
Adverse reactions associated with drugs presenting cutaneous manifestations are among the most common, expressing itself with multiple clinical aspects and causing significant morbidity. The fixed drug eruption (FDE) is a common adverse reaction with cutaneous involvement and is associated with the use of numerous drugs. Dipyrone is a drug with analgesic and antipyretic effects prescribed widely used in Brazil, however, it is known for its potential to triggering adverse reactions, including the FDE. This report shows an EMF case related to the use of dipyrone, with unique clinical presentation and correlate the clinical, histopathological and dermatoscopic found
Highlights
3 It was first described by Brocq,[1] Fixed drug eruption (FDE) clinically arises as a macular, erythematous-violaceous, oval lesion with recurrence in previously affected sites, triggered by the re-exposure to the involved drug.This eruption may occur in any body area, mainly affecting mucosal surfaces. 4, 5
In light of these facts, the authors of the present paper report a FDE case triggered by dipyrone, a drug that is widely used in Brazil, with few reports describing this association
Fixed drug eruption is a drug-related reaction linked to the use of numerous drugs (Table 1), 3-5,8,9 with no gender prevalence, predominantly occurring in the third decade of life. 3,4 Patients with family history of drug allergy or atopy have increased susceptibility to develop this pharmacodermy. 3
Summary
Authors: Maria Victória Quaresma[1] Luciana de Abreu[2] Lara Braga Oliveira[3] Bárbara Poggi[4] Thalyta Valley de Rezende[5] Bruna Souza Felix Bravo[6]. This study was performed at the Instituto de Dermatologia Professor Rubem David Azulay - Santa Casa da Misericórdia do Rio de Janeiro – Rio de Janeiro (RJ), Brazil. Fixed drug eruption on the face associated with dipyrone: correlation of clinical, histopathological and dermatoscopic findings. Erupção medicamentosa fixa na face associada a dipirona: correlação dos achados clínicos, histopatológicos e dermatoscópicos
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