Abstract
Modern appropriate treatment of hypertension involves the use of combination antihypertensive therapy. According to updated version of European Society of Cardiology 2018 guidelines, renin-angiotensin-aldosterone system blockers must be used as first-line drugs, including in combination with hydrochlorothiazide. This article presents the algorithms for the management of patients with uncomplicated and asymptomatic (with target lesions) arterial hypertension. It also described the management of patients with concomitant cardiovascular, cerebrovascular, renal pathology and diabetes mellitus, and use of fixed combination of candesartan and hydrochlorothiazide. The article presents research data that confirmed not only the high antihypertensive efficacy of this combination, but also demonstrated its neutral metabolic profile, organ-protective effects, the ability to use in patients with chronic kidney disease, chronic heart failure, prior stroke, as well as high tolerability and treatment adherence.
Highlights
Modern appropriate treatment of hypertension involves the use of combination antihypertensive therapy
According to updated version of European Society of Cardiology 2018 guidelines, renin-angiotensinaldosterone system blockers must be used as first-line drugs, including in combination with hydrochlorothiazide
This article presents the algorithms for the management of patients with uncomplicated and asymptomatic arterial hypertension
Summary
This article presents the algorithms for the management of patients with uncomplicated and asymptomatic (with target lesions) arterial hypertension It described the management of patients with concomitant cardiovascular, cerebrovascular, renal pathology and diabetes mellitus, and use of fixed combination of candesartan and hydrochlorothiazide. АГ — артериальная гипертензия, АГП — антигипертензивные препараты, АГТ — антигипертензивная терапия, АД — артериальное давление, АК — антагонист кальция, АТ II — ангиотензин II, АТ1-рецепторы — ангиотензиновые рецепторы 1 типа, АТ2-рецепторы — ангиотензиновые рецепторы 2 типа, БРА — блокатор рецептора ангиотензина II, ГЛЖ — гипертрофия левого желудочка, ГХТ — гидрохлортиазид, ДИ — доверительный интервал, иАПФ — ингибитор ангиотензин-превращающего фермента, ИБС — ишемическая болезнь сердца, ИМ — инфаркт миокарда, ЛЖ — левый желудочек, МИ — мозговой инсульт, ОР — относительный риск, РААС — ренин-ангиотензин-альдостероновая система, рСКФ — расчетная скорость клубочковой фильтрации, САД — систолическое АД, СД — сахарный диабет, СКФ — скорость клубочковой фильтрации, СН — сердечная недостаточность, СНнФВ — СН со сниженной фракцией выброса, СНсФВ — СН с сохраненной фракцией выброса, ССЗ — сердечно-сосудистые заболевания, ТД — тиазидный диуретик, ХБП — хроническая болезнь почек, ХСН — хроническая сердечная недостаточность, β-АБ — бета-адреноблокатор, ESC/ESH — European Society of Cardiology/European Society of Hypertension.
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