Abstract
Process intensity of fixed bed glass sphere culture systems is increased considerably by replacing solid glass spheres with open pore glass spheres. This technique demonstrates the possibility of having a system capable of both volumetric and cell density scale up and being suitable for substrate attached and suspension cells. The yields achieved for a number of attached cell lines (approximately 10(7)/ml) demonstrate an increase approaching one order of magnitude over solid glass spheres (approximately 10(6)/ml). Also suspension cells were successfully entrapped in the open pore structure with similar yields.
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