Fix it, don’t trash it: Ribosome maintenance by chaperone-mediated repair of damaged subunits

Abstract

Acute stressors or normal cellular function may result in ribosomal protein damage, which threatens the functional ribosome pool and translation. In this issue, Yang etal.1 show that chaperones can extractdamaged ribosomal proteins and replace them with newly synthesized versions to repair mature ribosomes.