Abstract
The synthesis and characterization of five-coordinate platinum(II) complexes of general formula [PtClX(NN)(uns)] (X=Cl, Me; NN=bidentate nitrogen ligands; uns=substituted alkene containing carboxy or amino groups) are described. In some cases, the hindered rotation of the prochiral unsaturated ligand around the Pt-alkene bond, alone or in conjunction with a ligand environment affording a stereogenic metal centre, gives rise to a mixture of different stereoisomers. Some of the obtained complexes were tested on the neuroblastoma cell line SK-N-MC and a considerable inhibition of cellular proliferation was detected.
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