Abstract
Abstract. The prophet of Pit1 (PROP1) gene encodes a paired class homeodomain transcription factor of 226 amino acids and is organized of 3 exons. PROP1 is necessary for the specification, differentiation and proliferation of cells. Its function is essential for anterior pituitary organogenesis, and heritable mutations in this gene are associated with combined pituitary hormone deficiency (CPHD) in human patients and animals (SAVAGE et al., 2003; CARVALHO et al., 2006). To date, no polymorphisms of the bovine PROP1 gene were described. In the present experiment, the 5' flanking region, the coding region and partial introns of bovine PROP1 were scanned for single nucleotide polymorphism (SNPs) in five cattle breeds of China.
Highlights
The prophet of Pit1 (PROP1) gene encodes a paired class homeodomain transcription factor of 226 amino acids and is organized of 3 exons
Five single nucleotide polymorphism (SNPs) were found in 5’ flanking region, exon 1 and intron 1 of the PROP1 gene in 606 unrelated cattle which belonged to five cattle breeds in China
PAN et al.: Five novel single nucleotide polymorphisms (SNPs) of the prophet of PIT1 (PROP1) gene in bovine (Nanyang cattle, 220; Qinchuan cattle, 136; Jiaxian cattle, 144; Holstein, 61; Angus, 45). The distributions of these alleles were showed in the Table. These discovered SNPs were deposited in GenBank (AccNo.:EF518217, EF518218, EF518219, EF518220, EF518221, EF518222, EF518223, EF518224, EF518225, EF518226, EF518227, EF518228, EF518229, EF518230, EF518231, EF518232, EF518233, EF518234)
Summary
The prophet of Pit1 (PROP1) gene encodes a paired class homeodomain transcription factor of 226 amino acids and is organized of 3 exons. Results: Five SNPs were found in 5’ flanking region, exon 1 and intron 1 of the PROP1 gene in 606 unrelated cattle which belonged to five cattle breeds in China
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