Abstract
Five new taraxerene-type triterpenes, 2-nor-D-friedoolean-14-en-28-ol (1), 2-nor-d-friedoolean-14-en-3α,28-diol (2), 6α-hydroxy-2-nor-D-friedoolean-14-en-3,21-dione (3), 6α,11α,29-trihydroxy-D-friedoolean-14-en-3,16,21-trione (4), and 6α,23,29-trihydroxy-D-friedoolean-14-en-3,16,21-trione (5), were isolated from the MeOH extract of the branch barks of Davidia involucrata, together with five known compounds. Their structures were elucidated by means of various spectroscopic analyses. Five of the identified compounds showed moderate cytotoxicities against the cell proliferation of SGC-7901, MCF-7, and BEL-7404.
Highlights
Davidia involucrata Baill., an ornamental tree known as the Chinese dove tree or handkerchief tree, is the only species in genus Davidia
The results provided important, evolutionary and chemotaxonomic knowledge of monotypic genus Davidia
The branch barks of D. involucrata were collected from Shennongjia Forest Region of Hubei province, P
Summary
Davidia involucrata Baill., an ornamental tree known as the Chinese dove tree or handkerchief tree, is the only species in genus Davidia. An initial and the only report of study on chemical components of D. involucrata besides our program appeared in 1989, which revealed the presence of sterols, tannins and triterpenes [4]. We have recently reported the identification of two novel 2-nor-ursane triterpenes having a unique five-membered A-ring from the water insoluble fraction of the branch barks of D. involucrata [13]. We report in this paper the structure elucidation of the new triterpenes, as well as the in vitro cytotoxic activities against three tumor cell lines (SGC-7901, MCF-7 and BEL-7404) of the isolated compounds
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