Five new mexicanolide type limonoids from Heynea trijuga

Wei Yang,Hong-Ping He,Yu Zhang,Yan Li,Shi-Fei Li,Ling-Mei Kong,Xiao-Jiang Hao

doi:10.1007/s13659-012-0040-1

Abstract

Five new mexicanolide-type limonoids, heytrijunolides A–E (1–5) were isolated from the branches and leaves of Heynea trijuga. The structures of these new compounds were elucidated on the basis of extensive spectroscopic analysis. Compound 3 showed weak cytotoxicity against HL-60, SMMC-7721 and A-549 human tumor cell lines with the IC50 values of 21.88, 20.66 and 12.70 µM, respectively. Electronic Supplementary MaterialSupplementary material is available for this article at 10.1007/s13659-012-0040-1 and is accessible for authorized users.

Highlights

Five new mexicanolide type limonoids from Heynea trijugaWei YANG,a,b Ling-Mei KONG,a,b Shi-Fei LI,a,b Yan LI,a Yu ZHANG,a,* Hong-Ping HE,a,* and Xiao-Jiang HAOa aState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China bGraduate University of Chinese Academy of Sciences, Beijing 100049, China
Limonoids are highly oxygenated and modified nortriterpenoids mainly found in the plants of the Meliaceae and Rutaceae families, which either containing or derived from a precursor with a 4,4,8-trimethyl-17-furanyl steroid skeleton, and have attracted continuous attention due to their diverse structures and significant biological activities
Previous investigation on the chemical constituents of the genus Heynea has yielded a series of new limonoids, including trijugin-type, 30nortrijugin-type, phragmalin-type, and mexicanolide-type

Summary

Five new mexicanolide type limonoids from Heynea trijuga

Wei YANG,a,b Ling-Mei KONG,a,b Shi-Fei LI,a,b Yan LI,a Yu ZHANG,a,* Hong-Ping HE,a,* and Xiao-Jiang HAOa aState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China bGraduate University of Chinese Academy of Sciences, Beijing 100049, China

Introduction

AcO MeO

Experimental Section