Abstract
• Five new diterpenoid alkaloids were isolated from Aconitum sczukinii Turcz. • New compound 1 is the first diterpenoid alkaloid that contains a lactone D ring. • A plausible biosynthetic pathway for the formation of 1 is proposed. Ten diterpenoid alkaloids, including five new ones, sczukiniline A–E ( 1 - 5 ), were isolated from the root of Aconitum sczukinii. Their structures were elucidated based on the interpretation of spectroscopic data (HRESI-MS, IR, 1D- and 2D-NMR). Among the five new diterpenoid alkaloids, 1 - 3 are hetidine-type C 20 -diterpenoid alkaloids, while compounds 4 and 5 are lycoctonine-type C 19 -diterpenoid alkaloids. Noteworthily, sczukiniline A ( 1 ) features a novel ester group between C-12 and C-14, forming a D ring containing a lactone structure, resulting in a new skeleton of hetidine-type C 20 -diterpenoid alkaloid.
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