Five in one therapy for graded treatment of haemophilic arthritis.

Abstract

Haemophilic arthritis is the most universal clinical appearance of haemophilia. Treatment of this disease has become an important and difficult issue worldwide until recently. To investigate the efficacy and safety of five in one therapy for graded treatment of haemophilic arthritis. Haemophilic arthritis was classified into grades I-IV according to severity and the standards of De Palma and Cotler. Under no application of FVIII/FIX replacement therapy state, the effect of five in one therapy (intra-articular cavity drug injection, oral drug preparation, physiotherapy, and prevention of haemorrhage and infection evoked by puncture) was observed in 1527 affected joints of 750 cases of haemophilic arthritis. After 20days treatment, all grade I and II, 94.98% of grade III and 56.16% of grade IV affected joints were completely relieved; 5.02% of grade III and 41.47% of grade IV affected joints were basically relieved; and 2.38% of grade IV were partially relieved. This resulted in short-term complete and basic relief of 98.56% (1505/1527) of all affected joints. After follow-up of 1-6years, 86.97% of the affected joints were completely relieved, without any adverse reaction or complication. The results suggest that five in one therapy is safe and effective for treatment of haemophilic arthritis, and provides a convenient, cost-effective way of preventing and treating deformity caused by haemophilic arthritis.