Abstract
The study of the calibration of a series of compounds of environmental concern (six perfluoroalkyl compounds (perfluorooctane sulfonic acid and five perfluoroalkyl carboxylic acids), three preservatives (methyl-, ethyl- and propylparabens) and the brominated flame retardant hexabromocyclododecane) by LC-MS/MS has been carries out, with a view to their simultaneous determination in samples of environmental interest. In some cases nonlinear calibration curves are obtained, but restricting the concentration range a linear model may be used to fit the data. Residual analysis has been performed in order to verify which models fit the data better, opting for a compromise decision given the apparent complexity of residuals plots. As Box states there are no perfect models (but models that work better than others).
Highlights
Method validation is an important requirement in the practice of chemical analysis
Residual analysis has been performed in order to verify which models fit the data better, opting for a compromise decision given the apparent complexity of residuals plots
This paper deals on the first ones: Linearity
Summary
Method validation is an important requirement in the practice of chemical analysis. General requirements in method validation for performance characteristics include, but are not limited to, linearity, accuracy, precision, sensibility and robustness [1] [2] [3]. An essential component of the measures that a laboratory should implement to allow it to produce reliable analytical data. This paper deals on the first ones: Linearity (calibration). Calibration is an essentials part of every quantitative analytical method [3]-[10] and correct performance of the so important step is a critical part of method development and validation.
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