Abstract
The retention patterns of 140Ba- 140La in the rat were studied by whole-body counting techniques. The animals lost 50% of the original radioactivity in about 6.5 days. In about 3–4 days, nearly 24–25% of the administered 140Ba- 140La was excreted, and 75–76% of the dose was retained. The activities of 140Ba- 140La in bone, muscle, and blood as a function of time are reported. The peak concentration of 140Ba- 140La was found in bone at the end of the fourth day. The parent ( 140Ba) and the daughter ( 140La) isotopes are nearly in transient equilibrium in the sample of 140Ba- 140La found in the bone at the end of the fourth day. The effective physical half-lives suggest that 140Ba shows more preference than 140La to accumulate in bone. The major route for the elimination of 140Ba- 140La seems to be the feces. About 8% of the dose of 140Ba- 140La was excreted in urine, while about 16% of the dose of 140Ba- 140La was eliminated by routes other than urine in 4 days after intraperitoneal administration of 140Ba- 140La. Kidney differentiates between the parent and the daughter isotopes because the ratio 140Ba: 140La is higher in the urine than in the dose of 140Ba- 140La. Renal tissue shows a preference to retain 140La.
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