Abstract
The dynamic spatial organization of the genome affects gene expression control at many scales, from stem cell marker expression to enhancer-promoter pairs affecting a single gene (1). The lack of dynamic measurements in single cells, however, has made it challenging to determine whether structure of the genome is actually a cause of these changes in gene expression, or an effect of altered transcriptional states. In this issue, Guan et al. (2) report a method that provides a first step toward this technical goal by allowing researchers to begin to look at the movement of multiple pieces of the genome in real time in living nuclei.
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