Fish protein hydrolysate supplementation improves vascular reactivity in individuals at high risk factors for cardiovascular disease: A pilot study

Abstract

The present study evaluates the effect of fish protein hydrolysate (FPH) ingestion on macro- and microvascular endothelial function and blood pressure (BP) in subjects at high risk of cardiovascular disease (CVD). In a randomized, placebo-controlled, double-blind, crossover design, twelve individuals ingested a single dose of FPH or PLA. Flow-mediated dilation (FMD) was used to evaluate the macrovascular endothelial function and near-infrared spectroscopy-derived muscle O2 desaturation and resaturation parameters were used to evaluate muscle O2 extraction and microvascular reactivity, respectively, during arterial occlusion test. FMD and muscle O2 saturation were assessed at 60−70 min after the nutritional intervention. A significant improvement in FMD (P < 0.001), and muscle O2 resaturation and desaturation parameters (P < 0.05) after FPH ingestion was observed. There was no significant difference in BP (P> 0.05). The data demonstrated that FPH ingestion acutely improved FMD and muscle O2 desaturation and resaturation parameters in individuals at high risk of CVD. Additionally, no changes in BP were observed.