Abstract
The effects of dietary fish oil on pro-inflammatory cytokines, nuclear factor-kappaB (NF-κB) and viral replication were studied in a murine model of AIDS. Sixty-four female C57BL/6 mice were divided into two dietary groups and fed either a corn oil or fish oil diet. After 4 weeks, each group was divided into two subgroups. One subgroup from each group was infected with LP-BM5 murine leukemia virus. At 4 and 10 weeks post-infection, one-half of the mice were sacrificed. Blood samples, and the spleens and livers were collected. The results demonstrated that when compared to corn oil, fish oil partially suppressed the virus-induced overproduction of serum IgG and IgM and the in vitro LPS-stimulated production of leukotriene B 4, tumor necrosis factor-α and interleukin-1β in splenocytes. Fish oil also partially suppressed NF-κB activation and viral replication in both tissues when compared to corn oil.
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