Abstract
In last few years scientists observed the development of procedures and markers for embryonic stem cell characterization. These contain the identification of parameters for optimal chimera and fish homologs/paralogs of mammalian pluripotency genes and their formation. In this concern, fish models as lower vertebrates represent a significant reference to study the conserved mechanisms underlying self-renewal and differentiation process.
Highlights
In last few years scientists observed the development of procedures and markers for embryonic stem cell characterization
These contain the identification of parameters for optimal chimera and fish homologs/paralogs of mammalian pluripotency genes and their formation
Long-term undifferentiated cell culture systems derived from inner cell mass of developing embryos are called as embryonic stern (ES) cell culture systems (Evans and Kaufman, 1981; Martin, 1981)
Summary
In last few years scientists observed the development of procedures and markers for embryonic stem cell characterization. These contain the identification of parameters for optimal chimera and fish homologs/paralogs of mammalian pluripotency genes and their formation. Long-term undifferentiated cell culture systems derived from inner cell mass of developing embryos are called as embryonic stern (ES) cell culture systems (Evans and Kaufman, 1981; Martin, 1981) These cells are pluripotent in nature and can be induced to differentiate into cells of different lineage. Fish have several technical advantages over other vertebrates such as high fecundity, large transparent embryos, and rapid development These features simplify manipulation and allow phenotypic observations of Copyright © All rights are reserved by Chandan H. He showed that by just expressing four transcription factors (OCt4, SOX2, KLF4, C/L myc) in any adult cells can be turned into iPSCs [5,6]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
