Abstract
Surgeons conducting bone grafting procedures have been in search of a bone graft substitute to avoid autogenous bone harvesting because of its associated complications. In the present study, the authors used fish bone and fish DBM in healing of a radial bone defect in a rat model. The 16 female Sprague–Dawley rats used in the present study were divided into the following four groups: autograft (positive control), untreated defect (negative control), and fish DBM, and fish bone graft as the experimental groups. Radiographs were taken in the 1st, 35th, and 56th post-operative days. Histopathological and biomechanical evaluations were performed in 56th post-operative day. The radiological, histopathological, and biomechanical evaluations revealed a superior rate of bone formation in the fish bone graft and autograft groups compared to those of the control. This study showed that the fish bone graft is effective in healing of the radial bone defect in rat.
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