FISH analysis reveals frequent co-occurrence of 4q24/ TET2 and 5q and/or 7q deletions

Roberta La Starza,Barbara Crescenzi,Valeria Nofrini,Gianluca Barba,Caterina Matteucci,Lucia Brandimarte,Valentina Pierini,Nicoletta Testoni,Pellegrino Musto,Stefania Paolini,Valentina Gianfelici,Clelia T Storlazzi,Antonio Pierini,Laura Berchicci,Paolo Gorello,Cristina Mecucci

doi:10.1016/j.leukres.2011.08.004

FISH analysis reveals frequent co-occurrence of 4q24/ TET2 and 5q and/or 7q deletions

Roberta La Starza, Barbara Crescenzi + Show 14 more

https://doi.org/10.1016/j.leukres.2011.08.004

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Journal: Leukemia Research	Publication Date: Sep 13, 2011
Citations: 10

Affiliation: University of Perugia, University of Bologna, Sapienza University of Rome, University of Bari Aldo Moro

#Fisher's Exact Test #7q Deletions + Show 8 more

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Abstract

We investigated TET2 deletion in 418 patients with hematological malignancies. Overall interphase FISH detected complete or partial TET2 monoallelic deletion ( TET2 del) in 20/418 cases (4.7%). TET2 del was very rare in lymphoid malignancies (1/242 cases; 0.4%). Among 19 positive myeloid malignancies TET2 del was associated with a 4q24 karyotypic abnormality in 18 cases. In AML, TET2 del occurred in CD34-positive hematopoietic precursors and preceded established genomic abnormalities, such as 5q− and −7/7q−, which were the most frequent associated changes (Fisher's exact test P = 0.000).

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