Abstract
The influence of substituents in position 6 of the pyridine nucleus on the Fischer cyclization of cyclohexanone pyrid-2-ylhydrazones under the action of various catalysts has been studied. It has been established that the yields of the “normal” indolization products, derivatives of 5,6,7,8-tetrahydro-α-carboline, increase regularly on passing from the unsaturated compound to the 6-methyl- and further to the 6-bromopyrid-2-ylhydrazones. The results obtained have been compared with the capacity of the pyridine nitrogen in the hydrazones mentioned for undergoing nucleophilic addition and substitution reactions.
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