Abstract
Objective:To evaluate fetal aortic Doppler for the prenatal diagnosis of hemoglobinopathies in the first trimester of pregnancy.Materials and Methods:Between January and November 2014, a total of 108 patients were enrolled in the study. The couples were carriers of either alpha/beta thalassemia, sickle cell disease or combined carriers of these and were admitted to Çukurova University Faculty of Medicine, Department of Obstetrics and Gynecology Prenatal Diagnosis Center. One hour before the chorionic villus sampling (CVS), patients were evaluated using fetal aortic Doppler. Pulsatility index, peak systolic velocity, and heart rate were noted.Results:There were no statistically significant differences in Doppler indices between different groups of CVS results when compared with the healthy controls.Conclusion:Fetal aortic Doppler investigation was found to be ineffective for the prenatal diagnosis of hemoglobinopathies.
Highlights
A hemoglobinopathy is a genetic defect that results in abnormal structure of one of the globin chains of the hemoglobin molecule
Beta-thalassemia is prevalent among Mediterranean people, whereas alpha-thalassemia is common in sub-Saharan Africa, the Mediterranean Basin, the Middle East, South Asia, and Southeast Asia
There was no statistically significant differences between the groups regarding the mean age of the women and crown-lump length (CRL) of fetuses based on chorionic villus sampling (CVS) results
Summary
Çetin et al Fetal aortic Doppler for hemoglobinopathies prenatal diagnosis using Doppler ultrasound may be another noninvasive method for the carriers. Materials and Methods One hundred eight patients were enrolled in this prospective study between January 2014 and November 2014. All patients and their husbands were carriers of either alpha/beta thalassemia, sickle cell disease or combined carriers of these. They were admitted to Çukurova University Faculty of Medicine, Department of Obstetrics and Gynecology Prenatal Diagnosis Center for the prenatal diagnosis of hemoglobinopathies. They all had CVS during 11 and 14 weeks of their pregnancy. Statistical analyses were performed using Statistical Package for the Social Sciences (SPSS) version 15 (SPSS, Inc., Chicago, IL)
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