First Toxicity Report of the BC2001 Trial: A Multicentre Phase III Randomised Trial of Radiotherapy with and without Synchronous Chemotherapy in Muscle Invasive Bladder Cancer ISCRTN No. 68324339, EUDRACT No. 2004-000164-26

Abstract

The BC2001 trial was set up to address whether the use of concomitant chemotherapy could improve locoregional control and whether radiotherapy volume modification could reduce late toxicity without detriment to tumour control. The trial was designed to assess initial toxicity, toxicity during treatment, and then at six months, twelve months and annually thereafter according to the CTC, RTOG and LENT/SOMA scales. The trial closed to accrual on 30 April 2008. This is the first report of this trial focusing on acute toxicity.